The Future of Anti-aging Treatments – Have you reached that point in your life where your body starts feeling a little less up to snuff? Maybe back pain has become your norm, joints start aching on chilly nights, and small cuts stop healing overnight.
While this may make you feel melancholic, getting older is normal. This age-related decline of your body may be concerning at first, but there are ways to feel younger. From treatments and supplements you can take to healthy habits you can adopt, techniques to slow the aging process are numerous and ever-expanding. Nowadays, promising treatments are popping up targeting aging on a molecular level, providing a wide range of long-term benefits.
What is NMN?
Nicotinamide mononucleotide (NMN) is a naturally occurring molecule mainly used for the production of nicotinamide adenine dinucleotide (NAD+) in the body. NMN is one of the NAD+ precursors, which means that having higher levels of NMN can lead to increased NAD+ levels.
NAD+ is an essential molecule for the human body. It plays a vital role in several important processes in the body such as energy metabolism and DNA repair. As an enzyme cofactor, several enzymes in our bodies are dependent on NAD+ to work.
How nicotinamide mononucleotide mitigates age-associated physiological decline
As we get older, our bodies produce lower levels of NAD+. This makes it harder for our bodies to repair cells and makes it easier to introduce metabolic disorders and age-related diseases. Since NMN levels have a crucial role in NAD+ production, increasing it should help slow aging caused by a deficiency in NAD+.
Animal studies have shown that increased levels of NAD+ can extend lifespan by fueling proteins called sirtuins, which help sustain genome integrity and cause reduced DNA damage. Human studies of NAD-fueled sirtuin activity are still ongoing, but there have been studies that show how NMN can increase telomere length in DNA. Telomeres protect the ends of chromosome DNA from damage, but they shorten over time from perpetual cell division until cell death. This leaves us vulnerable to age-related illnesses.
NMN appears to be effective against skin aging caused by exposure to particulate matter, commonly encountered through air pollution in cities. Particulate matter can cause oxidative stress to cells, which, according to research, can be relieved by the NMN molecule. Scientists have also done NMN research showing its protective effects against UV damage in mice.
Using nicotinamide mononucleotide as a dietary supplement
NMN and NAD+ can be found naturally in humans and can be produced by a healthy diet, but decreased NMN production is normal as we grow older. NMN products can help replenish NAD+ levels to maintain their beneficial effects. NAD+ is difficult to introduce to the body as is, but the smaller NMN can more easily permeate through cell membranes. NMN may be ingested in the form of dietary supplements. It is not a heavily regulated therapeutic drug. Many studies suggest that it is safe to consume with no reported toxic effects. It is recommended for adults aged 30 to 60 to take 500mg per day. Older adults can take higher doses of up to 750mg per day. However, it would be wise to seek professional medical advice before taking NMN to make sure it’s the right treatment for you and for you to be aware of any potential side effects.
It must be noted that while the supplements are available commercially, human clinical trials for NMN supplementation are still ongoing. The NMN supplement is deemed safe for animals, and the effects in human trials look promising. A clinical study involving oral administration of NMN to men over 65 years old (all healthy adults) showed enhanced muscle performance with no adverse effects. Another study showed how NMN can improve insulin sensitivity in prediabetic women. More clinical testing is required to ensure long-term safety and for it to potentially be an FDA-approved drug.
Other health benefits of nicotinamide mononucleotide
The benefits of NMN in our bodies are immense. Aside from its anti-aging properties, further research shows evidence of positive effects on overall health. In addition to helping with metabolism, DNA maintenance, and prevention of age-related conditions, it can improve sleep quality, blood flow, brain function, and heart function. It also limits liver damage.
Taking NMN to increase NAD+ levels in blood cells benefits the immune system and affects skeletal muscle aging. It also helps regulate our circadian rhythm. Some researchers believe that it can help with more critical health conditions like diabetes, neurodegenerative diseases (including Alzheimer’s disease), and cancer. NMN supplements truly have a big potential to increase life expectancy.
There are more potential benefits to humans that could be translated from animal trials. One study found NMN supplementation to have specific benefits in gut bacteria cultivation in mice. More studies on mice show how NMN treatment can prevent cognitive decline and further increase longevity.
With its great therapeutic potential, NMN supplements are certainly something to look out for. For more in-depth information, visit https://www.nmn.com/.
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